针对体外皮肤模型的复杂性:对尖端发展的回顾
Cristina Quílez1, Luís B Bebiano2, Eleri Jones3
1Bioengineering Department, Universidad Carlos III de Madrid, Leganés, Spain; Fundación Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz, Madrid, Spain.
The Journal of investigative dermatology
|August 11, 2024
概括
先进的体外皮肤模型显示出研究和产品测试的前景,减少了动物使用. 然而,为研究皮肤衰老和疾病创造生理上准确的模型仍在发展.
科学领域:
- 生物医学工程 生物医学工程
- 皮肤病学 皮肤病学
- 毒理学 毒理学 毒理学
背景情况:
- 在体外皮肤模型为药物,化品和医疗器械研究提供了动物试验的替代方案.
- 目前的模型范围从简单的细胞培养到复杂的3D工程组织.
- 一些模型已被批准用于临床前测试,但生理学上可靠的模型仍在开发中.
研究的目的:
- 审查复杂的体外人类皮肤模型的最新进展.
- 讨论这些模型在研究皮肤平衡,衰老和疾病中的应用.
主要方法:
- 审查当前关于体外皮肤模型开发的文献.
- 对不同体外模型复杂性的分析,从单层到器官类型和生物工程3D模型.
主要成果:
- 在开发复杂的体外皮肤模型方面取得了重大进展.
- 这些模型显示了研究复杂的生物过程的潜力,例如皮肤衰老和疾病.
- 在实现所有应用的充分生理相关性方面仍然存在挑战.
结论:
- 体外皮肤模型正在迅速发展,为研究和测试提供了有前途的替代方案.
- 需要进一步开发,以提高这些模型的生理学可靠性,以便进行全面的皮肤研究.
相关概念视频
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Hair and hair follicles are integral components of the integumentary system. Hair is a filamentous structure composed mainly of a protein called keratin. It is found on the surface of the skin throughout the body, except for areas such as the palms of the hands and soles of the feet.
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
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