范围审查探讨了治疗勃起功能障碍的局部药物疗法的进展
Yun-Jung Yang1, Eun-Jung Yang2, Se Young Choi3
1Department of Convergence Science, College of Medicine, Catholic Kwandong University International St Mary's Hospital, Incheon, 22711, Republic of Korea.
对勃起功能障碍 (ED) 的局部治疗显示出作为口服药物的有效和安全替代品的承诺. 这些新的凝为那些无法或不愿意使用化酶5抑制剂的男性提供了可行的选择.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
- 皮肤病学 皮肤病学
背景情况:
- 勃起功能障碍 (ED) 在老年男性中很普遍,通常与并发症有关.
- 口服化酶5抑制剂是标准的ED治疗方法,但有限制和禁忌.
- 局部凝正在成为ED的替代药理疗法.
研究的目的:
- 审查治疗ED的局部药物的疗效和安全性.
- 评估ED药物疗法通过皮肤传递系统的有效性.
主要方法:
- 在PubMed,Cochrane,Embase和Web of Science数据库中进行了搜索.
- 包括随机对照试验,调查用于阴茎的局部药物用于ED.
- 专注于评估治疗有效性和患者结果的研究.
主要成果:
- 局部阿尔普拉斯塔迪尔,甘三酸盐 (MED2005) 和MED3000在7篇文章中评估了3475名患者.
- 局部阿尔普拉斯塔迪尔在67-75%的患者中达到勃起,显著改善了国际勃起功能指数的得分.
- 在24周内,MED2005显示出快速的作用 (在10分钟内有效率为70%),MED3000在24周内将勃起功能域得分提高了5.73分.
- 局部ED疗法显示可接受的安全性.
结论:
- 局部药物是对ED的有效,耐受性良好的治疗方法,提供各种作用机制.
- 已经确定了一种具有较低副作用的快速作用局部药物.
- 局部疗法为那些无法使用口服化酶5抑制剂的患者提供了可行的替代方案,尽管与一线治疗直接比较尚未确定.
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