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Updated: Jun 4, 2026

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在雨水中的内分泌和神经毒性影响的以效应为导向的分析取决于排放

Nicolai Baetz1, Jorge Ricardo Cunha2, Fabian Itzel3

  • 1Institut für Umwelt & Energie, Technik & Analytik e. V. (IUTA), Bliersheimer Str. 58 - 60, 47229 Duisburg, Germany; Instrumental Analytical Chemistry, Faculty of Chemistry, University of Duisburg-Essen, Universitätsstr. 5, 45141 Essen, Germany; Centre for Water and Environmental Research (ZWU), University of Duisburg-Essen, Universitätsstr. 2, 45141 Essen, Germany.

Water research
|August 11, 2024
PubMed
概括

风暴水流失,由气候变化加剧,将大量内分泌干扰化合物引入水道. 综合下水道溢出 (CSO) 是主要的贡献者,甚至超过了废水处理厂的负载,突出了基于效应的监测的需要.

关键词:
综合下水道溢出情况以结果为导向的分析.内分泌影响 内分泌影响高性能薄层染色学 高性能薄层染色学神经毒性,内分泌干扰化合物风暴水的风暴水是什么意思

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...