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临界新生儿格拉姆阴性细菌感染的挑战和趋势:长达7年半的观察性研究
Isadora Caixeta da Silveira Ferreira1, Izabella Clara de Brito Machado2, Ralciane de Paula Menezes3
1Postgraduate Program in Health Sciences, Faculty of Medicine, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
American journal of infection control
|August 11, 2024
概括
新生儿的血流感染 (GNB-BSIs) 与之前的广泛抗生素使用有关. 这增加了多重耐药生物和死亡率,突出显示了监测的必要性.
科学领域:
- 新生儿重症监护室 (NICU) 的研究.
- 传染病流行病学 传染病流行病学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 在新生儿重症监护室 (NICU) 中,血流感染 (GNB-BSI) 构成重大威胁.
- 了解风险因素和结果对于有效管理至关重要.
研究的目的:
- 分析NICU中GNB-BSI的发病率,风险因素和死亡率.
- 确定与增加的GNB-BSI相关的特定抗微生物暴露.
主要方法:
- 追溯队列研究的设计.
- 分析2015年1月至2022年6月入住新生儿重症监护室的新生儿.
- 对感染率,风险因素和死亡率的统计分析.
主要成果:
- 在1495名新生儿中,5.2%患有GNB-BSI,每1000个患者日发生率为2.9.
- 之前使用的卡巴 (OR=514.4) 和第四代头素 (OR=66) 是显著的风险因素.
- 感染与长时间住院和死亡率增加相关 (10%-29.9%),其中2.3%的隔离物是抗卡巴胺的.
结论:
- 高GNB-BSI发病率与先前的广泛抗菌剂使用有关.
- 这有助于多重耐药生物和高死亡率.
- 积极监督对于控制NICU中的GNB-BSI至关重要.
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