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百日咳毒素依赖性和无依赖性保护由 Bordetella 百日咳对流感的保护
Thomas Belcher1, Loïc Coutte1, Anne-Sophie Debrie1
1Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL-Centre for Infection and Immunity of Lille, F-59000 Lille, France.
Microbes and infection
|August 11, 2024
概括
Bordetella pertussis 感染通过两种不同的机制保护人们免受 A 型流感病毒的影响. 一种涉及 pertussis toxin (PT) 和IL-17,以减少病毒复制,而另一种则提供了独立于PT和IL-17的保护.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 病毒学 病毒学
背景情况:
- 细菌-病毒联合感染很常见,但它们的相互作用仍然不清楚.
- 了解这些相互作用对于开发有效的治疗方法至关重要.
研究的目的:
- 为了研究 Bordetella pertussis 感染对 A 型流感病毒 (IAV) 感染的影响.
- 确定百日咳毒素 (PT) 在这种相互作用中的作用.
主要方法:
- 实验使用C57BL/6J小鼠和IL-17淘汰小鼠进行.
- 鼠被感染了B. pertussis菌株 (BPSM,BPRA) 带有或没有净化的PT.
- 随后的IAV挑战允许评估死亡率,体重减轻和病毒载量.
主要成果:
- 以前的B. pertussis感染 (BPSM或BPRA) 保护小鼠免受IAV诱导的死亡.
- 联合给药BPRA和PT增强了对减肥和减少病毒载荷的保护,与肺部IL-17A增加相关.
- 对病毒复制的保护依赖于IL-17,而对死亡率和体重减轻的保护则独立于IL-17和PT.
结论:
- B. pertussis感染通过两种途径提供了对IAV的保护.
- 一个途径涉及PT和IL-17,导致病毒复制减少.
- 第二个途径,独立于PT和IL-17,可以防止流感的严重程度,而不会影响病毒载量.
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