温度与2型糖尿病之间的关联:英国生物银行的一项前性研究
ShengYuan Wang1, YaTing Lei1, XiaoLi Wang1
1Department of Occupational Health, School of Public Health, Harbin Medical University, Harbin, PR China.
在不舒服的工作场所温度下工作增加了2型糖尿病 (T2D) 的风险. 交替的热和冷环境构成T2D发展的最高风险,特别是当与遗传倾向相结合时.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 遗传流行病学遗传流行病学
背景情况:
- 职业温度暴露是2型糖尿病 (T2D) 的潜在环境风险因素.
- 工作场所温度,遗传易感性和T2D风险之间的相互作用仍未得到充分研究.
研究的目的:
- 为了前性地研究工作场所温度变化与2型糖尿病 (T2D) 的发生率之间的联系.
- 评估环境工作温度和T2D相关遗传风险评分 (GRS) 对T2D发生的相互作用影响.
主要方法:
- 在103,215名英国生物库参与者身上使用了Cox比例危险 (CPH) 模型.
- 通过医院住院病例记录评估T2D发生情况.
- 计算了与T2D相关的基因风险评分 (GRS) 的加权值,并分析了生存关系.
主要成果:
- 在1,355,200.6人年的随访期间,共诊断出2436例T2D病例.
- 与舒适的环境相比,在不舒适的温度下工作 (冷,热或交替) 显著增加了T2D风险.
- 交替热和冷的工作环境显示了T2D的最高相关风险.
结论:
- 不舒服的工作场所温度与2型糖尿病的风险增加有关.
- 暴露于不断变化的环境温度是T2D发展和严重程度的最重要的风险.
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