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孕期服用Bifidobacterium dentium会导致代际调节炎症,代谢和社会行为的结果

Jeffrey D Galley¹, Mackenzie K King², Therese A Rajasekera¹

¹Department of Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Institute for Behavioral Medicine Research, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Brain, behavior, and immunity

|August 11, 2024

概括

孕妇补充Bifidobacterium dentium可以对抗产前压力影响. 这种益生菌干预改善了母亲和后代的健康,减少了炎症并增强了后代的社会行为.

科学领域:

微生物组研究的研究.
神经科学是一个神经科学.
孕产妇和胎儿的健康状况

背景情况:

产前压力 (PNS) 对母亲和后代的健康产生负面影响,导致微生物组的改变,神经炎症和行为问题.
PNS破坏了托芬代谢,并减少了有益的肠道Bifidobacteria,与神经发育的好处有关.
婴儿的Bifidobacterium dentium减少与母亲的产前情绪障碍有关.

研究的目的:

调查是否用B. dentium补充PNS暴露的孕妇可以减轻PNS诱导的健康缺陷在母体和后代.
评估B. dentium对炎症标志物,托代谢和后代行为的影响.

主要方法:

孕妇暴露于产前压力的孕妇补充了B. dentium.
测量包括炎症输出,托代谢物水平和母体和胎儿的基因表达.
后代的社会行为在成年后被评估.

主要成果:

B. dentium补充剂减少了母亲的全身炎症和胎儿的神经炎症.
托代谢受到调节,基努伦酸和英多尔-3-酸在代际之间增加.
防止了PNS诱导的子体重减少,后代表现出更好的社交性 (雄) 和社会新性 (雌性).

结论:

B. dentium有效地改善产前压力诱导的免疫,代谢和行为缺陷,无论是母体还是后代.
B. dentium显示出作为预防性策略的潜力,可以应对产前压力的不良影响.
这项研究强调了特定益生菌在调解代际健康结果中的作用.

关键词:

双杆菌是一种细菌.孕期益生菌孕期益生菌在产前的压力,产前的压力.跨代传输是跨代的传输托芬代谢的代谢方式

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