跨导管大动脉置换后的性别差异和长期临床结果:一项SWEDEHEART研究
Michael Dismorr1, Malin Granbom-Koski1, Emma Ellfors2
1Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Cardiothoracic Surgery, Karolinska University Hospital, Stockholm, Sweden.
American heart journal
|August 11, 2024
概括
雌性经历更好的生存率和更低的出血风险经过过导管大动脉置换 (TAVR). 这些发现强调了在TAVR患者管理中考虑性别特异性因素的重要性.
科学领域:
- 心血管医学 心血管医学
- 干预心脏病学 干预心脏病学
- 健康 结果 研究 研究 结果
背景情况:
- 跨导管大动脉置换 (TAVR) 结果中的性别差异与之前的研究相矛盾.
- 需要对按性别分层的长期风险和收益进行全面分析.
研究的目的:
- 为了比较TAVR后的女性和男性之间的长期死亡率,心力衰竭住院,心肌梗塞,中风,出血和再干预率.
- 为了确定TAVR后的结果的性别特异性差异.
主要方法:
- 全国范围,基于人口的队列研究,使用SWEDEHEART注册表 (2008-2022年).
- 包括10475名接受TAVR治疗的患者,使用国家卫生登记册的数据.
- 应用回归标准化来调整基线性别差异.
主要成果:
- 女性 (47%) 在10年内,与男性相比,全因死亡风险较低 (绝对差异为6.4%).
- 女性也有明显较低的重大出血风险 (10年绝对存活率差异为4.0%).
- 在心力衰竭,心肌梗塞,中风或重新干预的风险方面没有观察到任何显著的性别差异.
结论:
- 女性在TAVR后表现出优异的长期存活率和降低的出血风险.
- 针对性别的考虑对于优化接受TAVR的患者的管理和护理至关重要.
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