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Updated: Jun 17, 2025

Establishment of an Extracellular Acidic pH Culture System
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细胞内pH差异调节正常上皮细胞中代谢和信号通路的转录

Ricardo Romero-Moreno1, Brandon J Czowski1, Lindsey Harris1

  • 1Harper Cancer Research Institute, South Bend, Indiana, USA; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.

The Journal of biological chemistry
|August 11, 2024
PubMed
概括

在正常细胞中改变细胞内pH值 (pHi) 会引发广泛的基因表达变化,影响信号传递和新陈代谢. 高pHi促进癌症类代谢转变和健康细胞中的乳酸生产.

关键词:
这是Notch1信号.葡萄糖溶解是什么细胞内部的pH值乳酸乳酸是一种乳酸.代谢过程中的代谢.皮鲁酸是一种酸盐.

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