在青春期暴露于口服LSD后,大脑结构和功能的发育变化
Lila Harris-Blum1, Zachary Smith1, Richard J Ortiz2
1Center for Translational NeuroImaging, Northeastern University, Boston, MA, USA.
Scientific reports
|August 11, 2024
概括
青少年暴露于lysergic acid diethylamide (LSD) 并没有影响年轻成年小鼠的认知或运动行为. 然而,多次LSD剂量改变了大脑的微观结构,并减少了功能连接,这表明神经可塑性发生了持久的变化.
科学领域:
- 神经科学是一个神经科学.
- 神经生物学 神经生物学 神经生物学
- 发展心理学 发展心理学
背景情况:
- Lysergic acid diethylamide (LSD) 是一种强大的幻觉剂,已知可以诱导复杂的神经生物学和行为效应.
- 这些效应被认为是通过大脑神经可塑性的改变来调解的.
- 青春期代表了神经可塑性增强的关键窗口,特别是在前脑.
研究的目的:
- 为了研究长期的发育影响LSD暴露在青春期期间对大脑结构和功能.
- 检查单次和多次LSD剂量对认知和情绪行为,神经解剖学和神经电路的影响.
- 为了确定在这个敏感的发育期内接触LSD是否会导致大脑的持久变化.
主要方法:
- 雌性和雄性小鼠从出生后51天开始通过口腔试管接受载体,单剂或多剂量的LSD (3.3μg).
- 在产后90-120天之间,小鼠接受了MRI (基于声素的形态测量,扩散加权成像,静止状态fMRI) 和认知和运动功能的行为测试.
- 用3D小鼠大脑图谱分析MRI数据,以确定大脑结构和功能连接的特定位置差异.
主要成果:
- 青少年LSD暴露对年轻成年小鼠的运动行为或认知表现没有显著影响.
- 实验组之间的大脑体积差异是最小的,并且不局限于特定区域.
- 多次LSD暴露显著改变了灰色物质的微观架构,特别是在丘脑,感觉/运动皮层和基底,这是扩散加权成像 (DWI) 变化所表明的.
- 在多剂量LSD暴露后,前脑白质道和感觉运动皮层/海马体之间的功能连接减少.
结论:
- 虽然LSD暴露在近青春期小鼠中没有产生可观察到的认知或运动行为的缺陷,但它诱导了大脑微观架构和功能连接的显著改变.
- 观察到的灰色物质微观架构的变化和功能连接的减少表明对神经可塑性和神经电路的持久影响.
- 需要进一步的研究,以充分阐明这些LSD诱导的神经生物学变化的行为后果.
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