诺纳罗西卡 (Boraginaceae) 提取物的植物化学特征和抗菌作用
V V Velichko1, M E Kartashova2, S D Kucherova2
1Novosibirsk State Medical University, Novosibirsk, Russia. velichkvik@rambler.ru.
概括
诺纳罗西卡草本提取物富含黄化合物,如黄酸和基酸,具有显著的抗微生物和抗真菌特性. 乙醇提取物证明对黄金葡萄球菌,大麦芽菌和白菌的有效性.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
背景情况:
- 诺纳罗西卡斯蒂文 (Boraginaceae) 是一种在俄罗斯广泛发现的植物物种.
- 植物的空气部位 (草药) 传统上被使用,需要对其化学成分和生物活性进行科学研究.
研究的目的:
- 为了研究Nonea rossica的植物化学特征.
- 评估其提取物的抗微生物和抗真菌特性.
- 为了确定提取基生物活性化合物 (BACs) 的最佳乙醇度.
主要方法:
- 使用薄层染色学对BAC进行定性分析.
- 通过光谱测量对化合物 (黄,酸,氨酸,氨酸) 的定量分析.
- 抗微生物和抗真菌活性测定使用序列稀释方法对金黄色葡萄球菌,谷物菌和白菌进行测定.
主要成果:
- 鉴定和量化了包括基胺酸,黄酸和氨酸在内的酸BACs.
- 使用40-70%的乙醇提取物获得了性BAC的最高产量.
- 用40-70%乙醇制备的提取物显示出针对格拉姆阳性细菌的显著抗菌活性和针对Candida albicans的抗真菌活性.
结论:
- 罗西卡草 (Nonea rossica) 含有具有显著抗微生物和抗真菌潜力的化合物.
- 乙醇度在40-70%之间是提取这些生物活性化合物的最佳水平.
- 咖啡酸和氨酸等化合物的协同相互作用有助于观察到的杀菌和杀真菌作用.
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