尿路多环芳和金属的同时暴露对肺功能的影响:系统性炎症的调解作用
Lihong Wu1,2,3, Xue Lu4, Siying Zhang1
1Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, China.
BMC pulmonary medicine
|August 11, 2024
概括
同时暴露于多环芳 (PAH) 和金属会显著损害肺功能. 白血细胞 (WBC) 计数部分调解了这种关系,突出了呼吸系统健康干预的关键毒素.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 多环芳 (PAH) 和金属与肺功能减弱有关.
- 同时暴露的综合效应和潜在机制在很大程度上是未知的.
研究的目的:
- 调查PAHs和金属对肺功能的同时暴露的影响.
- 探索外围白细胞 (WBC) 计数在这些关联中的调解作用.
主要方法:
- 对1,123名美国成年人的尿路PAHs,金属和WBC计数进行分析 (NHANES 2011-2012).
- 测量了五个肺功能指数.
- 应用统计模型,包括贝叶斯核机器回归和基于量子的g计算,用于同时暴露效应.
- 调解分析以评估WBC的作用.
主要成果:
- 在PAHs,金属和肺功能受损之间发现了显著的关联.
- 特定的PAHs (2-Hydroxyphenanthrene,3-Hydroxyfluorene) 和被确定为主要的贡献者.
- 白细胞计数介于8.22%-23.90%的PAH和肺功能之间的关联.
结论:
- 同时接触PAH和金属会对肺功能产生负面影响.
- 白血球部分调解PAH与肺功能之间的关系.
- 针对特定的有毒物质可以减轻对呼吸系统健康的不良影响.
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