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持续局部抗生素 perfusion 对于足部和脚的深层感染

Hirofumi Nakajima¹, Satoshi Yamaguchi², Seiji Kimura¹

¹Graduate School of Medical and Pharmaceutical Sciences, Chiba University, Chiba, Japan.

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

|August 12, 2024

概括

在大多数患者中,持续局部抗生素 perfusion 有效控制了深部脚部和脚感染. 这种创新的治疗方法为具有挑战性的骨科条件提供了有希望的选择,最大限度地减少了进一步手术的需要.

科学领域:

整形外科手术整形外科手术
传染性疾病传染性疾病
药理学药理学是指药理学的学科.

背景情况:

深足和脚感染在骨科中是一个重大的临床挑战.
有效的治疗策略对于预防并发症和改善患者结果至关重要.

研究的目的:

评估持续局部抗生素 perfusion 治疗深部脚部和脚感染的疗效.
评估与这种治疗方法相关的感染复发率和不良事件.

主要方法:

11名患有足部和脚深部感染的患者接受了手术脱bridement,随后进行了为期两周的持续局部抗生素 perfusion.
高度的珍塔素 (60毫克/50毫升) 通过骨髓针和双亮管直接输送到受感染的骨和软组织中.
系统地记录了患者的人口统计,感染复发和不良事件.

主要成果:

在11名患者中,10名患者在不需要额外的手术干预的情况下实现了感染控制.
平均随访期为40个月,在大多数情况下显示持续有效性.
没有任何不良事件被归因于高度的 gentamicin perfusion,尽管有两名患者出现了可保守管理的真菌感染.

结论:

持续局部抗生素 perfusion 提供了一个可行的治疗选择,深足和脚感染.
这种方法实现了短期感染控制,并可能减少进一步手术的需要.
进一步的研究可能会探索长期结果和最佳抗生素度.

关键词:

脚脚在脚上连续的局部抗生素 perfusion perfusion 是一种持续的局部抗生素 perfusion.深度感染的感染.脚脚脚脚脚脚脚脚骨髓炎是一种骨质炎.

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