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心灵饮食,大脑转录基因变化和痴呆症

Jun Li1,2, Ana W Capuano3,4, Puja Agarwal3,5

  • 1Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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概括

一种健康的饮食,就像MIND饮食一样,与独特的大脑基因表达特征有关. 这种特征与老年人的认知衰退速度减慢和痴呆症风险降低有关.

关键词:
地中海饮食方法阻止高血压干预神经退行性延迟 (MIND) 饮食衰老的衰老 衰老的衰老认知能力下降 认知能力下降皮层的基因表达.痴呆症 痴呆症是一种痴呆症.健康的饮食模式健康的饮食模式

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科学领域:

  • 神经科学是一个神经科学.
  • 遗传学 是一个遗传学.
  • 营养科学 营养科学

背景情况:

  • 饮食模式显著影响痴呆风险,但潜在的分子途径仍然在很大程度上未被阐明.
  • 了解连接饮食和大脑健康的生物机制对于开发有效的痴呆症预防策略至关重要.

研究的目的:

  • 确定与坚持MIND饮食 (地中海饮食方法停止高血压干预神经退行性延迟) 相关的大脑转录形状.
  • 调查与饮食相关的转录组形状和认知健康轨迹 (包括全球认知和痴呆风险) 之间的联系,在老年人中.

主要方法:

  • 从宗教秩序研究和记忆和衰老项目的1204名参与者的死后前额叶皮层获得的RNA测序数据.
  • 在482个个体中,识别了一种与MIND饮食得分相关的50基因转录组签名.
  • 在剩余的722名参与者中,检查了这种转录组特征得分与认知衰退和痴呆发病率之间的关联.

主要成果:

  • 确定了50个基因的显著转录基因特征,并与MIND饮食得分相关 (p=0.001).
  • 较高的转录基因特征得分与全球认知能力每年下降的速度较慢 (β=0.011,p=0.003) 和痴呆的几率降低 (OR=0.76,p=0.0002).
  • TCIM和IGSF5的基因表达可能调解了MIND饮食和痴呆症之间的关系.

结论:

  • 已经确定了一个与健康饮食模式,特别是MIND饮食相关的大脑转录形状.
  • 这种特征与更好的认知健康有关,并可能揭示影响认知衰老和痴呆风险的新基因.
  • 需要进一步的研究来证实因果关系,并探索已识别的基因在调解饮食与大脑相互作用中的功能作用.