克罗恩病患者的肠道准备质量尺度的表现
Virginia Solitano1,2,3, Corey A Siegel4, Joshua R Korzenik5,6
1Department of Medicine, Division of Gastroenterology, Western University, London, Ontario, Canada.
Alimentary pharmacology & therapeutics
|August 12, 2024
概括
大多数仪器可靠地评估克罗恩病患者的肠道准备质量. 这支持它们在临床实践和新肠道制备剂试验中的使用.
科学领域:
- 胃肠病学 胃肠病学
- 内镜检查是指内镜检查.
- 临床试验 临床试验
背景情况:
- 克罗恩病 (CD) 患者的肠道准备 (BP) 的有效性仍未确定.
- 精确评估血压质量对于CD患者的有效结肠镜检查至关重要.
研究的目的:
- 评估用于评估CD患者血压质量的各种仪器的性能.
- 为了确定这些工具的可靠性和有效性.
主要方法:
- 使用多种尺度:波士顿肠道准备量表,修改的波士顿肠道准备量表,Harefield清洁量表,食品和药物管理局肠道清洁评估量表 (BCAS),以及视觉模拟量表.
- 评估了40名CD患者的50个视频,评估了血压质量和内镜疾病活性 (CD简单内镜评分 - SES-CD).
- 使用类内相关系数 (ICC) 量化可靠性,并通过仪器和SES-CD分数之间的相关性来确定有效性.
主要成果:
- 所有仪器都表现出相当大的分级间和分级内可靠性 (ICC ≥0.61),视觉模拟尺度显示出几乎完美的分级内可靠性 (ICC ≥0.81).
- 美国食品和药物管理局的BCAS在插入时显示了较低的评审者间可靠性 (ICC ≥0.41).
- 有效性相关性超过0.58,血压质量与结肠内镜疾病活性有负相关性.
结论:
- 大多数当前的仪器可靠地评估CD患者的BP质量.
- 这些发现支持在临床实践中使用这些仪器,并在CD临床试验中评分BP质量.
- 这项研究为评估CD患者的新BP药物提供了基础.
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