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小分子光探针的进步用于研究亡

Ya-Xi Ye¹, Jian-Cheng Pan², Hai-Chao Wang¹

¹Institute of Pharmaceutical Biotechnology, School of Biology and Food Engineering, Suzhou University, Suzhou 234000, P. R. China. hsxyzxt@163.com.

Chemical Society reviews

|August 12, 2024

概括

小分子光探针 (SMFP) 能够实时可视化细胞亡,这是一个关键的细胞死亡过程,与癌症等疾病有关. 本综述强调了SMFP最近的发展,以改善亡研究和诊断.

科学领域:

生物化学生物化学
分子生物学分子生物学
细胞生物学细胞生物学

背景情况:

细胞亡或编程细胞死亡对于生物调节至关重要,并与许多疾病有关,包括癌症和神经退行性疾病.
由于缺乏有效的实时工具,无法在生物系统中进行非破坏性可视化,因此无法理解亡机制.
小分子光探针 (SMFP) 已成为在体外和体内成像亡的强大工具,有助于疾病诊断和治疗.

研究的目的:

审查设计用于亡成像的小分子光探针 (SMFP) 的最新进展.
总结针对亡的SMFP的共同设计策略.
讨论SMFPs在亡研究中的当前局限性和未来前景.

主要方法:

文献综述侧重于过去15年来用于亡成像的SMFPs.
基于它们的向机制 (例如,酶活性,等离子体膜变化,反应性物种,微环境) 的SMFP的分类.
分析探头设计原理及其在研究亡中的应用.

主要成果:

最近的SMFP利用了多种机制,包括酶活性,血变化,反应性氧/硫物种和微环境变化,用于检测亡.
已经确定了针对细胞亡的SMFP的可通用设计原则.
SMFPs为体外和体外亡成像提供了显著的潜力,有助于疾病诊断和治疗.

结论:

SMFPs是推动我们对亡及其在各种疾病中的作用的理解不可或缺的工具.
持续开发具有增强灵敏度,特异性和实时成像能力的新型SMFP至关重要.
本综述提供了全面的概述,并确定了SMFPs在亡相关领域的未来研究方向.

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