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在 homo-d 配置的 RNA 和 DNA 上 homo-l 体世界的逐渐演变
Ewa Węgrzyn1, Ivana Mejdrová1, Thomas Carell1
1Department of Chemistry, Center for Nucleic Acids Therapies at the Institute for Chemical Epigenetics (ICE-M), Ludwig-Maximilians-Universität (LMU) München Butenandtstrasse 5-13 81377 Munich Germany thomas.carell@lmu.de.
Chemical science
|August 12, 2024
概括
这项研究揭示了早期生命可能是如何倾向于l-氨基酸的,这导致 homochiral 蛋白质的进化. 在d配置的核酸上的合成选择性地产生l-氨基酸链,解释了大自然的偏好.
科学领域:
- 生物化学 生物化学
- 生命的起源 生命的起源
- 分子生物学分子生物学
背景情况:
- 遗传信息翻译通过蛋白质将基因型与表型联系起来.
- 生物系统仅使用l-氨基酸进行蛋白质合成,与d-配置的核酸形成鲜明对比.
- 以前的研究表明,在d配置的寡核酸上合成时,l-氨基酸具有选择性.
研究的目的:
- 进一步研究在d配置核酸上的化合成中观察到的l-氨基酸选择性.
- 探索合成/再捕获循环的潜力,以丰富同体性l-的形成.
- 要确定这种选择性是否延伸到DNA,超出RNA.
主要方法:
- 研究了发生在homo d配置的寡核酸 (RNA和DNA) 上的合成.
- 利用合成/再捕获周期来评估特定配置的丰富性.
- 对比同质素l-的竞争力与混合l/d-立体化学的.
主要成果:
- 证明了一种合成/再捕获循环,驱动 homochiral l-的逐渐丰富.
- 显示混合l/d-立体化学与同体性l-不具有竞争力.
- 证实RNA和DNA在合成中都表现出l-氨基酸偏好.
结论:
- 在d配置核酸上观察到的l-氨基酸选择性支持同型的l-世界演变.
- 这种机制为我们提供了关于在早期地球上同类性如何演变的见解.
- 这些发现突出了生物同化性起源的一个基本原则.
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