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从人工智能辅助血管学评估辐射壁应变:可行性和与OCT作为参考标准的协议
Jiayue Huang1, Shengxian Tu2, Chunming Li2
1The Lambe Institute for Translational Medicine, Smart Sensors Laboratory and Curam, University of Galway, Galway, Ireland.
概括
人工智能现在从冠状动脉血管学 (RWSAngio) 中计算了辐射壁应变,显示了与光学连贯断层扫描 (RWSOCT) 的出色一致. 这种快速,具有成本效益的方法为评估冠状动脉生物力学提供了一种新的方法.
科学领域:
- 心血管成像 - 心血管成像
- 生物机械分析 生物机械分析
- 人工智能在医学中的应用
背景情况:
- 冠状动脉中高压力区域表明斑块脆弱性,并预测不良心血管事件.
- 人工智能 (AI) 能够从冠状动脉血管学 (RWSAngio) 中计算辐射壁应变.
- 具有有限元分析 (FEA) 的光学连贯性断层扫描 (OCT) 是RWS (RWSOCT) 的确立参考.
研究的目的:
- 评估RWSAngio和RWSOCT之间的协议.
- 评估使用人工智能用于从血管造影计算RWS的可行性.
- 为了比较RWSAngio与RWSOCT分析的效率.
主要方法:
- 来自前一项研究的OCT数据与冠状动脉血管学一起被注册.
- 使用基于心脏周期期间相对光线变形的AI计算RWSAngio.
- RWSOCT是使用OCT截面上的FEA衍生出来的,与RWSAngio定义相匹配.
主要成果:
- RWSAngio与RWSOCT有很强的相关性和一致性 (r=0.91,林系数=0.85).
- 与健康人群相比,动脉样硬化部分的RWSAngio显著更高 (12.6%对4.5%).
- 对RWSAngio的观察者内部和观察者间变异性很高 (ICC 0.92和0.88). 对RWSAngio的分析时间显著减少 (0.9分钟对RWSOCT的95.0分钟).
结论:
- 辐射壁应变可以通过使用人工智能从冠状动脉血管学快速计算.
- RWSAngio显示与参考标准RWSOCT非常一致.
- 这种新的方法为大量人群提供了潜在的成本效益高的生物力学评估.
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