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研究甲状腺功能障碍与血清脂质异常之间的关联
Ibrahim Al-Odat1, Saad Al-Fawaeir1, Malik H Al-Mahmoud2
1Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, Jadara University, Irbid 21110, Jordan.
甲状腺功能障碍显著影响脂质谱,增加心血管疾病风险. 这项研究强调了对公共查和教育的需要,以管理约旦人甲状腺疾病和相关的失脂症.
科学领域:
- 内分泌学 在内分泌学.
- 心血管健康 心血管健康
- 临床生物化学 临床生物化学
背景情况:
- 甲状腺功能障碍的患病率正在全球范围内上升.
- 甲状腺疾病与不良的脂质特征变化有关.
- 脱脂症是心血管疾病的重要危险因素.
研究的目的:
- 为了确定约旦人口中甲状腺功能障碍的患病率.
- 调查甲状腺功能障碍与血清脂质概况之间的关联.
- 评估甲状腺功能障碍对脂质障碍和心血管风险的影响.
主要方法:
- 一项涉及228名约旦受试者的横截面研究.
- 参与者被分为甲状腺功能障碍 (n=178) 和对照 (n=50) 组.
- 测量了甲状腺刺激激素,自由甲状腺素 (FT4),自由三甲状腺素 (FT3),总胆固醇 (TC),LDL,HDL和甘油三 (TG) 的血清水平.
主要成果:
- 甲状腺功能障碍在75%的参与者中普遍存在,在女性中更为普遍.
- 具体的患病率包括明显的甲状腺功能低下症 (17.4%),亚临床的甲状腺功能低下症 (43.8%),明显的甲状腺功能过高症 (18.4%),以及亚临床的甲状腺功能过高症 (20.4%).
- 甲状腺功能低下症与TC,LDL和TG升高有显著关联,48.4%的甲状腺功能低下患者表现出高胆固醇血症和32.3%的高甘油三血症.
结论:
- 查和教育的公共卫生举措对于管理甲状腺功能障碍至关重要.
- 甲状腺功能障碍和脂质异常之间存在着强烈的联系.
- 在甲状腺功能障碍患者中,定期监测血脂障碍和心血管疾病是必不可少的.
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