血管风险因素与认知衰退之间的关系中的性别差异:英国生物库研究
Amanpreet Kaur1,2, Moustafa H Fouad1, Chelsea Pozzebon1
1Department of Medicine, McGill University Health center, Montreal, Canada.
JACC. Advances
|August 12, 2024
概括
血管风险因素对男性和女性的认知衰退的影响不同. 虽然整体下降率相似,但女性经历的更大的负面影响来自诸如高血压和LDL胆固醇等因素.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 公共卫生 公共卫生
背景情况:
- 与年龄相关的认知衰退是由与大脑小血管疾病相关的血管风险因素加剧的.
- 这些血管风险因素在性别特异性认知衰退模式中的作用尚不清楚.
研究的目的:
- 为了研究随着时间的推移认知能力下降的性别差异.
- 检查血管风险因素与认知衰退之间的关联,将性别视为一个因素.
主要方法:
- 利用了来自55岁以上的19,000多名英国人生物库数据.
- 在2014年至2019年期间评估认知功能 (执行功能,处理速度,记忆).
- 采用回归和混合效应模型来分析认知衰退和性别特异性风险因素相互作用.
主要成果:
- 最初,女性在所有认知领域的得分较低.
- 在矩阵模式完成过程中观察到显著的性别-时间相互作用,在调整血管风险因素后,这种相互作用减少了.
- 高的LDL胆固醇,低教育和高血压不成比例地加快了与男性相比,女性的执行功能下降.
结论:
- 在研究期间,认知衰退率在性别之间没有显著差异.
- 特定血管风险因素对认知能力下降率的影响在女性比男性更为明显.
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