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Updated: Jun 17, 2025

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
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生物催化, (Z/E) -三替代乙醇的立体合基化

Runze Mao1, Doris Mia Taylor1, Daniel J Wackelin1

  • 1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, 91125, United States.

Nature synthesis
|August 12, 2024
PubMed
概括

研究人员设计了一种细菌细胞染色体P450酶,SCA-G2,以实现立体融合基功能化. 这种生物催化剂有效地将两种E/Z异构体转化为立体纯产品,简化了奇拉基合成.

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