在肝硬化中肠道微生物群和细胞因子概况
Irina Efremova1, Roman Maslennikov1, Anna Kudryavtseva2
1Department of Internal Medicine, Gastroenterology and Hepatology, Sechenov University, Moscow, Russia.
Journal of clinical and translational hepatology
|August 12, 2024
概括
肝硬化患者的肠道功能障碍与更高水平的有害细菌和内毒性相关. 这些因素与增加的促炎性细胞因子直接相关,表明肠道健康和疾病严重程度之间存在显著的关系.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 肠道功能失调和异常的细胞因子概况在肝硬化中很普遍.
- 了解肠道微生物群和免疫反应之间的相互作用对于治疗肝硬化至关重要.
研究的目的:
- 在肝硬化患者中研究肠道失调和细胞因子概况之间的相关性.
- 识别与改变的免疫标记物相关的特定微生物种群.
主要方法:
- 多重检测测量27种细胞因子在血中的量化.
- 血中亚酸盐和脂聚糖 (LPS) 的测量.
- 16S rRNA基因测序用于便微生物群分析.
主要成果:
- 与对照组相比,肝硬化患者表现出IL-1b,IL-2,IL-6,TNF-a,LPS和酸盐的水平升高.
- LPS和亚酸盐水平与各种细胞因子和疾病严重程度标志物 (如炎) 有显著的相关性.
- 包括Enterobacteriaceae和Klebsiella在内的特定细菌种类与TNF-a和IL-6等促炎性细胞因子具有积极的相关性.
结论:
- 有害的肠道微生物群和内毒素的丰富性与肝硬化中炎症性细胞因子水平的升高直接相关.
- 这些发现强调了肠道微生物群在调节免疫反应和肝硬化疾病进展中的作用.
关键词:
末端毒性病 (Endotoxemia) 是一种导致内毒性病的疾病.最后毒素 (Endotoxin) 是一种内毒素.我们的肠道微生物组.肠 - 肝轴 肠 - 肝轴有漏洞的肠道系统性炎症是一种系统性炎症.更多相关视频
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