在严重的COVID-19患者中,肠道性酸酶的活性和效率发生变化
João R Araújo1,2, Thainá Serafim1, Shámila Ismael1,2,3
1Nutrition & Metabolism Department, NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, Lisboa, Portugal.
Gastro hep advances
|August 12, 2024
概括
严重的COVID-19患者表现出肠道性酸酶 (iALP) 活性和细菌脂多糖化物 (LPS) 水平降低. 然而,iALP与LPS的比率增加了,这表明在严重的情况下,肠道失调症的补偿机制存在.
科学领域:
- 胃肠病学 胃肠病学
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道炎症和失生症与严重的COVID-19有关.
- 肠道性酸酶 (iALP) 在COVID-19严重性中的作用尚未得到充分研究.
- 细菌脂多糖 (LPS) 是一种由肠道衍生的促炎分子.
研究的目的:
- 为了比较轻度至中度和严重的COVID-19患者的iALP活性和LPS度.
- 为了调查iALP,LPS和COVID-19严重程度之间的关系.
- 在COVID-19病理生理学中探索潜在的肠道相关机制.
主要方法:
- 分析了来自53名轻度至中度和57名重度COVID-19患者的便样本.
- 测量肠道性酸酶 (iALP) 活性.
- 便细菌脂聚糖化物 (LPS) 度的量化.
主要成果:
- 与轻度至中度病例相比,在严重的COVID-19患者中,iALP活性降低了40% (P=.04).
- 在重症患者中,便中LPS度下降 (P=.01),但与C-反应蛋白无关.
- 在严重的COVID-19患者中,便iALP活动/LPS度比较高 (P=.04).
结论:
- 在严重的COVID-19中,iALP活动的减少可能是补偿反应.
- 改变iALP动力学可能在严重的COVID-19期间在控制肠道失调症方面发挥作用.
- 这些发现突出了严重的COVID-19潜在的肠道向治疗策略.
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