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血清维生素D水平与视网膜血管阻塞之间的关联:系统性审查和元分析

Atitaya Apivatthakakul¹, Suthinee Jaruvongvanich², Sikarin Upala³

¹Ophthalmology, Chiang Mai University, Chiang Mai, THA.

|August 12, 2024

概括

维生素D缺乏与视网膜血管封闭 (RVO) 有关. 这次元分析发现,RVO患者的维生素D水平显著降低,这表明缺乏是危险因素.

科学领域:

眼科医生眼科眼科
内分泌学在内分泌学.
营养科学营养科学

背景情况:

视网膜血管封闭 (RVO) 发生率呈季节性变化,冬季的发病率较高.
新出现的证据表明,维生素D缺乏和RVO之间存在联系.
维生素D在血管健康和免疫功能中起着至关重要的作用.

研究的目的:

进行一项元分析,评估维生素D水平与RVO之间的关联.
确定维生素D缺乏是否是RVO的重要风险因素.
为了比较不同RVO亚型的维生素D水平.

主要方法:

在MEDLINE和EMBASE数据库中进行全面的文献搜索 (开始至2024年2月).
包括观察性研究,比较成人RVO患者的血清25-基维生素D (25(OH) D水平与非RVO对照.
使用随机效应模型和通用逆方差方法进行统计分析,以计算 95% 置信区间 (CI) 的聚合平均差异 (MD) 和赔率比率 (OR).

主要成果:

包括528名参与者 (228名RVO,300名对照) 的5项研究.
在RVO患者中观察到明显较低的血清25(OH) D水平 (总体MD: -9.65;95%CI: -13.72至 -5.59).
维生素D缺乏 (血清25(OH) D<20 ng/mL) 与RVO有很强的关联 (合并OR:14.52;95%CI:1.72~122.59).

结论:

与对照人群相比,RVO患者的血清维生素D水平明显较低.
维生素D缺乏是RVO的潜在危险因素.
临床医生应该考虑查RVO患者的维生素D缺乏;对补充剂的进一步研究是有必要的.

关键词:

25 氧维生素 d 维生素d 的含量分支视网膜静脉闭塞视网膜静脉闭塞这是一个元分析.维生素D水平维生素D水平维生素D 缺乏症维生素D 缺乏症

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