挥发性有机化合物的潜力用于诊断原发性硬化胆管炎
Robert van Vorstenbosch1, Kim van Munster2, Georgios Stavropoulos1
1Department of Pharmacology and Toxicology, NUTRIM School of Nutrition and Translational Research, Maastricht University, Maastricht, The Netherlands.
JHEP reports : innovation in hepatology
|August 12, 2024
概括
呼出的气息挥发性有机化合物在患有炎症性肠道疾病 (IBD) 的患者中显示出非侵入性检测原发性硬化胆管炎 (PSC) 的前景. 这种呼吸试验可以帮助早期诊断PSC,即使在早期阶段,改善患者的结果.
科学领域:
- 肝病学和胃肠道学
- 生物标志物发现发现
- 分析化学 分析化学
背景情况:
- 初级硬化性胆道炎 (PSC) 是一种病因不明的慢性肝病,与炎症性肠病 (IBD) 密切相关.
- 由于缺乏特定的生物标志物,早期诊断PSC具有挑战性,往往导致在不可逆转的肝损伤后启动治疗.
- 目前用于PSC的诊断方法具有侵入性,可能无法在早期阶段检测到疾病.
研究的目的:
- 评估呼气中挥发性有机化合物 (VOC) 的诊断潜力,以检测早期的PSC.
- 评估VOC是否可以区分PSC患者 (有或没有IBD) 和没有PSC的IBD患者.
- 探索特定的VOC与PSC疾病预后的相关性.
主要方法:
- 从患有单独PSC,单独PSC和IBD,单独IBD的患者收集了呼吸样本.
- 气色谱-质谱法用于分析呼吸样本中的挥发性有机化合物.
- 采用随机森林建模来识别有歧视性的VOC,并开发一个预测诊断模型,在一个独立的测试集上进行验证.
主要成果:
- 使用20种挥发性有机化合物的预测模型在区分PSC与IBD方面获得了77%的灵敏度和83%的特异性.
- 该模型显示,接收机操作曲线下的面积为0.84,表明了良好的诊断性能.
- 三种特定的VOCs (异烯,2-octanone,undecane) 与PSC疾病预后得分有显著的相关性.
结论:
- 呼出的气息挥发性有机化合物可以有效地区分PSC患者与单独IBD患者.
- 这种呼吸分析具有作为早期检测PSC的非侵入性诊断工具的巨大潜力.
- 这些发现支持开发用于早期PSC诊断的临床呼吸试验,可能改善管理和结果.
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