尿道上腺素硫酸盐可以预测中度至重度OSA的心血管风险:一种基于代谢学的研究
Yuxin Wang1, Xiaona Wang1,2, Jinmei Luo1
1Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
Nature and science of sleep
|August 12, 2024
概括
泌尿代谢学可以预测阻塞性睡眠呼吸暂停 (OSA) 的心血管风险. 尿液中的上腺素硫酸盐水平是早期检测OSA患者心血管并发症的关键指标.
科学领域:
- 代谢学 代谢学 代谢学
- 心血管医学 心血管医学
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 具有显著的心血管风险.
- 目前用于预测OSA心血管风险的指标不足.
- 尿道代谢学为早期风险评估提供了一种新的方法.
研究的目的:
- 利用泌尿代谢学来识别中度至重度OSA患者的早期心血管风险标志物.
- 调查与OSA相关的代谢途径改变.
- 确定特定代谢物对OSA心血管风险的预测值.
主要方法:
- 招募的男性参与者接受了多睡眠图.
- 收集了临床,多睡眠和尿液样本.
- 进行非向性尿道代谢学,随后进行多变量和ROC分析.
- 通过回归和调解分析,研究了代谢物,临床指标和心血管风险之间的关联.
主要成果:
- 通过各种途径识别了65种代谢物,包括pyrimidine和类固醇代谢.
- 尿道上腺素硫酸盐显著改变,显示高AUC (0.883) 检测中度至重度的OSA.
- 上腺素硫酸盐与OSA严重程度,缺氧,动脉硬以及弗雷明汉心血管风险相关.
- 上腺素硫酸盐预测了增加的弗雷明汉风险和动脉增大指数,部分由血压介导.
结论:
- 中度至重度的OSA与尿路代谢途径的显著改变有关.
- 尿道上腺素硫酸盐作为OSA患者早期心血管风险的强有力的预测剂.
- 代谢分析可以增强OSA心血管风险分层.
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