身体虚弱和退行性膜心脏病的风险
Xinli Guo1, Ziang Li1, Tianxin Long1
1Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Innovation in aging
|August 12, 2024
概括
身体脆弱和脆弱前期显著增加患心脏膜疾病 (VHD) 的风险. 早期检测和干预脆弱性可以帮助预防或延迟老年人VHD发病.
科学领域:
- 老年学是一门学科.
- 心血管医学 心血管医学
- 公共卫生 公共卫生
背景情况:
- 身体虚弱与退行性膜心脏病 (VHD) 之间的联系尚不清楚.
- 与年龄相关的疾病和脆弱性可能会影响VHD的发展.
研究的目的:
- 调查身体虚弱与退行性VHD发病率之间的关联.
- 为了确定与VHD风险相关的脆弱组件.
主要方法:
- 利用了英国生物库数据,这些数据来自没有VHD或心力衰竭的参与者.
- 根据5个组成部分将个人分为非脆弱,脆弱前和脆弱组.
- 在中位数为13.8年的时间里,评估了心肌反,大动脉反和大动脉狭窄的发生率.
主要成果:
- 与不虚弱相比,虚弱前和虚弱与MR,AR和AS的风险显著增加.
- 缓慢的步行速度是所有VHD类型的最强预测因素,其次是疲劳,握力低,体重减轻.
- 分析了超过331,000名参与者,其中3.6%被归类为脆弱,43.2%被归类为脆弱前.
结论:
- 虚弱前期和虚弱与退行性VHD的风险增加有关.
- 针对老年人脆弱性的干预措施可能有助于预防或延迟VHD.
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