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哺乳动物条状内部神经元的保护,改变和重新分配

Emily K Corrigan^1,2, Michael DeBerardine³, Aunoy Poddar^1,2

¹Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.

bioRxiv : the preprint server for biology

|August 12, 2024

概括

在哺乳动物中保留了TAC3内部神经元初始类,显示神经元分布和命运精炼的进化变化,而不是新型前体的发展.

科学领域:

神经科学是一个神经科学.
进化生物学进化生物学
基因组学就是基因组学.

背景情况:

哺乳动物大脑的进化涉及细胞类型的变化,但像灵长类动物特有的TAC3内神经元这样的新型神经元的起源尚不清楚.
了解特定神经元种群在物种中的分布对于破译大脑进化至关重要.

研究的目的:

研究哺乳动物中TAC3内神经元的空间和遗传分布.
为了确定TAC3内部神经元是灵长类动物特有的创新还是进化保存的细胞类型.

主要方法:

在发育中的猪和中进行单细胞基因表达概况分析.
对成年老鼠神经元前体种群的分析.
跨物种抑制性神经元类别的比较分析.

主要成果:

TAC3内部神经元的初始类在波里欧特里亚哺乳动物中保存,早于灵长类的进化.
在猪和中,这种祖先种群在条纹体和皮层中都存在.
鼠标条状内神经元的一个子集表达TAC2,TAC3的正方体,表明保存的发育途径.

结论:

电脑抑制神经元的初始类型在哺乳动物中很大程度上保留了.
神经元类型的进化多样化是通过重新分配和命运改进而发生的,而不仅仅是通过新型前体的出现.
这挑战了TAC3内神经元作为灵长类动物特有的创新概念.

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Neuroplasticity

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Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.