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Updated: Jun 17, 2025

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
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Published on: June 3, 2018

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综合性转录因子扰动重新总结了纤维细胞转录状态

Kaden M Southard1, Rico C Ardy1, Anran Tang1

  • 1Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

bioRxiv : the preprint server for biology
|August 12, 2024
PubMed
概括

研究人员开发了CRISPR激活 (CRISPRa) Perturb-seq以在体外重现细胞状态. 这种方法确定了KLF4和KLF5作为具有治疗潜力的通用细胞状态的关键调节者.

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Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
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