治疗易感或耐药结核病的患者的微生物群变化
M Hauptmann1, B Kalsdorf2,3, J E Akoh-Arrey1
1Priority Area Infections, Division of Cellular Microbiology.
IJTLD open
|August 12, 2024
概括
抗结核病疗法显著改变人类微生物群,特别是在耐药结核病 (DR-TB) 患者中,导致多样性减少和病原体增加. 这些发现凸显了DR-TB治疗对肠道和呼吸道微生物群的影响.
科学领域:
- 微生物学 微生物学
- 人类微生物组研究研究
- 传染性疾病 传染性疾病
背景情况:
- 结核病 (TB) 治疗方案可能会影响人类微生物群.
- 了解这些变化对于治疗结核病,特别是耐药结核病 (DR-TB) 至关重要.
研究的目的:
- 调查抗结核病疗法期间人类微生物群组成的变化.
- 为了将这些变化与Mycobacterium tuberculosis的药物反应水平相关联.
主要方法:
- 对从未接受过治疗的结核病,药物敏感结核病 (DS-TB) 和不同形式的DR-TB的参与者的便,唾液和口腔拭片样本的分析.
- 在治疗27-42天后收集样本.
主要成果:
- 与DS-TB和未经治疗的群体相比,DR-TB患者的便样本中的α多样性减少,这表明显著的dysbiosis.
- 在DR-TB患者的唾液中增加了Lactobacillus属的丰富性.
- 在接受注射药物治疗的DR-TB患者的口腔抽样中扩大了医院肺炎相关的类型.
结论:
- 针对DR-TB的二线抗结核疗法显著改变了人类微生物群.
- 变化包括微生物多样性的减少和潜在有害细菌 (病原生物) 的增加.
- 这些微生物组的变化可能会对DR-TB治疗期间的患者健康产生影响.
更多相关视频
10:04Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
18.8K
09:57System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
Published on: April 5, 2017
8.6K
相关概念视频
Pulmonary Tuberculosis I
227
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
227
Pulmonary Tuberculosis V
176
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
176
Pulmonary Tuberculosis IV
134
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
134
Pulmonary Tuberculosis II
215
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
215
Pulmonary Tuberculosis III
316
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
316
