3D打印形状记忆聚合物的制造取决于差异生物降解
Ryan Akman1, Harsha Ramaraju1, Samuel Moore1
1Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 313 Ferst Dr. NW, Atlanta, GA 30332.
Virtual and physical prototyping
|August 12, 2024
概括
研究了3D打印的烯酸聚糖 - 十二二酸盐 (APGD) 的降解. 材料挤出显示了更快的降解,但APGD植入物没有表现出炎症,表明在组织工程中临床使用的潜力.
科学领域:
- 组织工程是组织工程.
- 生物材料科学是生物材料的科学.
- 聚合物化学 聚合物化学
背景情况:
- 3D打印的形状记忆聚合物 (SMP) 正在在组织工程中获得吸引力.
- 了解降解对于SMPs的临床转化至关重要.
- 材料性质的变化会影响in vivo性能.
研究的目的:
- 为了研究3D打印的烯酸聚甘二甲酸 (APGD) 的降解.
- 为了比较三种制造方法的降解:材料挤出,激光切割和光聚合.
- 评估体外 (水解,酶) 和体内降解行为.
主要方法:
- 在体外进行水解和酶降解试验.
- 在动物模型中进行体内皮下植入.
- 分析质量损失,体积损失和融化过渡温度.
- 对周围组织进行组织学检查.
主要成果:
- 与激光切割和光聚合样品相比,2个月后,材料挤出样品的质量和体积损失显著增加.
- 在体外降解导致APGD的融化过渡温度增加.
- 在活体中,降解并没有导致融过渡温度发生显著变化.
- 组织学显示,在APGD植入物周围没有显著的炎症.
结论:
- 制造方式影响3D打印APGD的降解率.
- 在活体中,APGD表现出生物相容性,没有显著的炎症反应.
- 3D打印的APGD显示出在组织工程中的临床应用的前景.
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