相关实验视频

Updated: Jun 17, 2025

Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models

Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models

Published on: May 10, 2022

细胞外膀衍生非编码RNA在糖尿病病中的作用

Miao Hu¹, Xiahong Shen¹, Ling Zhou¹

¹Department of Nephrology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Kidney diseases (Basel, Switzerland)

|August 12, 2024

概括

携带非编码RNA (ncRNA) 的细胞外囊泡 (EV) 在糖尿病病 (DKD) 进展中起着关键作用. 了解这些EV衍生的ncRNA为DKD的诊断和治疗提供了潜力.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
分子生物学分子生物学
生物化学生物化学

背景情况:

糖尿病病 (DKD) 是糖尿病的常见并发症,其特点是功能受损.
细胞外囊泡 (EVs) 正在成为DKD病变发生的关键调解者.
EVs运输生物活性分子,特别是非编码RNA (ncRNA),影响DKD进展.

研究的目的:

审查电动汽车在DKD中的机械作用.
阐明在DKD中EV衍生的ncRNAs的功能相关性.
讨论在DKD中EV衍生的ncRNAs的临床潜力.

主要方法:

在DKD中对EV和ncRNA的研究的文献综述.
在DKD病变发生过程中EV功能的分类 (炎症,氧化应激,EMT,细胞死亡,ECM沉积).
对来自EV的ncRNAs的诊断和治疗应用的当前研究进行分析.

主要成果:

来自EV的ncRNA通过各种机制调节基因表达.
这些ncRNAs有助于DKD表型,如炎症,氧化应激和纤维化.
来自EV的ncRNAs显示出作为生物标志物和DKD的治疗点的希望.

结论:

电动汽车及其ncRNA货物是DKD发展和进步的组成部分.
来自EV的ncRNAs代表了在DKD中新型诊断和治疗策略的有希望的途径.
对EV-ncRNA相互作用的进一步研究对于DKD管理中的临床转化至关重要.

关键词:

糖尿病脏疾病糖尿病脏疾病诊断生物标志物诊断生物标志物细胞外囊泡中的细胞外囊泡.没有编码的RNA.治疗目标是治疗的目标.

更多相关视频

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

Overview of Exosomes

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...

Nephrons

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...

Renal Corpuscle

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...

Insulin Secretory Vesicles

Insulin Secretory Vesicles

Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...

Types of RNA

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...