全球胆道癌的发生率和死亡率 胆道癌的全球发生率和死亡率
Katherine Baria1, Enrico N De Toni2, Binbing Yu3
1Global Medical Affairs, AstraZeneca Pharmaceuticals, Gaithersburg, Maryland.
Gastro hep advances
|August 12, 2024
概括
全球胆道癌 (BTC) 发病率和死亡率因国家和亚型而异. 不断上升的趋势突出显示,迫切需要改善所有BTC的预防和治疗策略,包括胆囊癌 (GBC) 和胆管癌 (ICC).
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 胆道癌 (BTC) 涵盖了多种肝脏和周肝瘤,包括胆囊癌 (GBC),胆管癌 (ICC) 和父癌囊 (AVC).
- 现有的研究往往聚合BTC亚型或将其与其他肝癌混为一谈,需要明确的流行病学更新.
- 这项研究提供了BTC发病率和死亡率的全面全球概述,分析了不同解剖亚型的变化.
研究的目的:
- 介绍全球胆道癌 (BTC) 发病率和死亡率的描述性更新,总体和具体的解剖亚型.
- 确定BTC流行病学的地理变化和时间趋势.
- 为了突出BTC亚型和性别之间的发病率和死亡率模式的差异.
主要方法:
- 使用年龄标准化率每10万人/年.
- 数据来源于国际癌症癌症发病率研究机构在五大洲 (2008-2012; 22个国家).
- 纳入世界卫生组织死亡数据库记录 (2006-2016; 38个国家).
主要成果:
- 在全球范围内,BTC发病率各不相同,智利的发病率最高 (14.35),越南的发病率最低 (1.25).
- 死亡率在韩国 (11.64) 最高,在摩尔多瓦共和国 (1.65) 最低,在34个国家中24个国家观察到上升趋势.
- 在大多数地区,胆囊癌 (GBC) 的发病率最高,而肝内胆管癌 (ICC) 的死亡率最高. 血管癌 (AVC) 总是发生率和死亡率最低. 女性更频繁地受到GBC的影响,而男性显示出较高的ICC发病率和死亡率,额外肝胆管癌和AVC.
结论:
- 该研究揭示了BTC发病率和死亡率在亚型之间存在显著的全球差异.
- 越来越多的BTC发病率和死亡率趋势强调了加强公共卫生干预措施的关键需要.
- 针对性预防和治疗策略对于所有胆道癌症亚型至关重要,考虑到它们独特的流行病学特征.
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