多重歧视暴露和生物衰老:美国中年研究的结果
Adolfo G Cuevas1,2, Steven W Cole3, Daniel W Belsky4
1Department of Social and Behavioral Sciences, New York University School of Global Public Health, New York, NY, USA.
Brain, behavior, & immunity - health
|August 12, 2024
概括
经历过歧视会加速生物衰老,导致健康差异. 减少歧视可能会促进健康老龄化和健康公平.
科学领域:
- 社会流行病学 社会流行病学
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 歧视是健康差距的一个关键社会决定因素.
- 将歧视与健康状况不佳联系在一起的生物学机制尚未得到充分理解.
- 这项研究探讨了歧视对生物衰老过程的影响.
研究的目的:
- 调查歧视是否加速生物衰老.
- 检查歧视类型与表观遗传衰老之间的关联.
- 确定介导歧视与老龄化之间的联系的因素.
主要方法:
- 分析了美国中年期 (MIDUS) 研究的调查和DNA甲基化数据 (N=1967).
- 使用线性回归来评估日常,主要和工作场所歧视与表观遗传钟之间的关系 (DunedinPACE,PhenoAge,GrimAge2).
- 研究了吸烟状态和体重指数作为潜在调解者的作用.
主要成果:
- 报告的更高的歧视与更快的生物衰老 (DunedinPACE) 和更老的生物年龄 (PhenoAge, GrimAge2) 相相关.
- 对于日常/重大歧视而言,协会比工作场所歧视更强大.
- 吸烟和BMI解释了大约一半的观察到的关联.
- 歧视对老龄化的影响在白人参与者中更为明显,尽管黑人参与者中的歧视报告较高,老龄化速度更快.
结论:
- 歧视有助于加速生物衰老.
- 减少歧视和促进应对的干预措施可以支持健康老龄化和健康公平.
- 需要进一步的研究来了解种族差异对歧视对衰老的影响.
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