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Updated: Jun 17, 2025

Identification of Homologous Recombination Events in Mouse Embryonic Stem Cells Using Southern Blotting and Polymerase Chain Reaction
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基因组广泛的有条件小鼠淘汰赛资源

C Kaloff1, K Anastassiadis2, A Ayadi3

  • 1Institute of Developmental Genetics, Helmholtz Zentrum Muenchen, D-85764 Neuherberg, Germany.

Drug discovery today. Disease models
|August 12, 2024
PubMed
概括

国际淘汰赛小鼠联盟在小鼠胚胎干细胞中创造了超过18,500个基因突变,导致成千上万的突变小鼠菌株和用于研究的创造驱动器菌株. 这些资源可以在www.mousephenotype.org.org上找到.

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In-vitro Mutagenesis01:16

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To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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