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相关概念视频

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To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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  1. 首页
  3. 基因组广泛的有条件小鼠淘汰赛资源
  1. 首页
  3. 基因组广泛的有条件小鼠淘汰赛资源

相关实验视频

Identification of Homologous Recombination Events in Mouse Embryonic Stem Cells Using Southern Blotting and Polymerase Chain Reaction
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基因组广泛的有条件小鼠淘汰赛资源

C Kaloff1, K Anastassiadis2, A Ayadi3

  • 1Institute of Developmental Genetics, Helmholtz Zentrum Muenchen, D-85764 Neuherberg, Germany.

Drug discovery today. Disease models
|August 12, 2024

在PubMed 上查看摘要

概括
此摘要是机器生成的。

国际淘汰赛小鼠联盟在小鼠胚胎干细胞中创造了超过18,500个基因突变,导致成千上万的突变小鼠菌株和用于研究的创造驱动器菌株. 这些资源可以在www.mousephenotype.org.org上找到.

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Generating CRISPR/Cas9 Mediated Monoallelic Deletions to Study Enhancer Function in Mouse Embryonic Stem Cells
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Mouse Genome Engineering Using Designer Nucleases
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Generating CRISPR/Cas9 Mediated Monoallelic Deletions to Study Enhancer Function in Mouse Embryonic Stem Cells
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科学领域:

  • * 遗传学和基因组学
  • * 哺乳动物遗传学
  • * 鼠标模型 鼠标模型

背景情况:

  • * 国际淘汰赛鼠标联盟 (IKMC) 建立了用于基因捕捉和准的高通量管道.
  • *这项计划在C57BL/6N小鼠胚胎干细胞 (ES) 中产生了超过18,500个基因的条件突变.
  • *这些ES细胞系被归档并作为研究界的冷资源提供.

研究的目的:

  • * 创建并提供用于遗传研究的老鼠模型的综合图书馆.
  • * 通过标准化小鼠菌株来促进基因疾病关联的分析.
  • *通过提供多样化的遗传工具集合来支持生物医学研究.

主要方法:

  • * 在小鼠ES细胞中高通量基因捕捉和基因向.
  • * 对大量基因产生条件突变.
  • *开发可诱导的培养驱动器小鼠菌株和培养驱动器RAAVs.

主要成果:

  • * 在存档的ES细胞中,有超过18,500个基因具有条件突变.
  • * 超过6000个突变的老鼠菌株已经由IKMC和国际老鼠表型化联盟 (IMPC) 生成.
  • *建立了250个可诱导的cre-driver小鼠菌株和27个cre-driver rAAVs的资源.

结论:

  • * IKMC/IMPC资源提供了一个具有定义遗传背景的标准化小鼠模型库.
  • *这些资源使得在不同的遗传背景下分析基因疾病关联.
  • *预计IKMC/IMPC资源将对生物医学研究产生重大影响.