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Chronic Salmonella Infection Induced Intestinal Fibrosis
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低饮食黄酸盐消费与严重的炎症性肠病有关
Beatrice Kölbel1, Stefanie Hamacher2, Martin Hellmich2
1Department of Internal Medicine and Gastroenterology, Evangelisches Krankenhaus Kalk, University of Cologne, Cologne, Germany.
Gastro hep advances
|August 12, 2024
概括
较高的黄类药物消费与较轻的炎症性肠病 (IBD) 严重程度有关. 低摄入的黄类药物显著增加了严重IBD和疾病进展的风险,特别是在性结肠炎.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 免疫学 免疫学 免疫学
背景情况:
- 饮食习惯与炎症性肠病 (IBD) 有关.
- 在水果,蔬菜和绿茶中发现的黄酸具有屏障保护和抗炎性质.
- 黄类消费 (FC) 可能会影响IBD的严重程度.
研究的目的:
- 调查黄类消费 (FC) 在炎症性肠病 (IBD) 的过程和严重性中的作用.
主要方法:
- 一项前性队列研究,涉及204名IBD患者 (克罗恩病和性结肠炎) 从2016-2021年.
- 使用问卷来评估黄类药物 (FC) 的消耗.
- 严重性指数与个人FC相关,以及标准活动得分和治疗.
主要成果:
- 观察到FC和IBD严重程度之间存在反向相关性 (r = -0.0549; P = .01).
- 患有轻度IBD的患者比患有严重IBD (331±330 mg/周;P<.001) 患者摄入的黄显著更多 (1404±1086 mg/周).
- 低FC (<1000 mg/周) 与严重IBD的风险增加了17倍 (P < .001) 和性结肠炎患者的疾病进展风险增加了9.6倍 (P < .001).
结论:
- 饮食中的黄类药物消费与炎症性肠道疾病的严重程度相反相关.
- 较高的黄类药物摄入量与较轻的疾病有关.
- 低摄入的黄类药物代表了严重IBD和疾病进展的显著风险因素.
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