在没有ST段升高的情况下,Troponin-T在医院外心脏骤停的预后价值:一项COACT子研究
Eva M Spoormans1, Jorrit S Lemkes1, Gladys N Janssens1
1Department of Cardiology, Amsterdam University Medical Center, location VUmc, Amsterdam, the Netherlands.
没有ST升高的心脏骤停患者可以从监测心脏中托罗-T (cTnT) 水平中获益. 升高的cTnT及其时间度曲线 (T-AUC) 预测死亡率和急性冠状动脉病变,有助于风险分层.
科学领域:
- 心脏病学 心脏病学
- 紧急医疗 紧急医疗
- 生物标志物研究 生物标志物研究
背景情况:
- 没有ST升高的非医院心脏骤停 (OHCA) 患者缺乏急性冠状动脉综合征风险的可靠标志物.
- 准确预测OHCA急性冠状动脉综合征对于及时干预和改善结果至关重要.
研究的目的:
- 在没有ST升高的OHCA患者中,研究心脏热素-T (cTnT) 和其时间度曲线 (T-AUC) 的预后值.
- 为了确定cTnT水平与90天生存率之间的关联,急性血栓塞,急性不稳定病变和左心室功能.
主要方法:
- 在心脏骤停 (COACT) 后冠状动脉血管学试验的后期分析.
- 在352名OHCA患者的住院后0,3,6,12,24,48,72小时测量cTnT.
- 统计分析以评估cTnT测量 (中位数,T-AUC) 与临床结果之间的关联,以混因素进行调整.
主要成果:
- 所有cTnT测量,包括中位数cTnT和T-AUC,都是90天死亡率的独立预后因素.
- 中位数cTnT和T-AUC独立预测了急性不稳定病变和急性血栓塞.
- cTnT值与左心室功能没有显著关联.
结论:
- 在前72小时内,心脏中托罗-T (cTnT) 释放动力学与没有ST段升高的OHCA患者的临床结果有关.
- cTnT监测可以帮助识别急性冠状动脉综合征的高风险患者,并预测这一群体的死亡率.
更多相关视频
08:19Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs
Published on: July 12, 2022
05:26Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
Published on: May 28, 2019
相关概念视频
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Electrocardiogram
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
Exercise Stress Test
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
