与 gabapentinoids 相关的妄想不良事件:基于 FAERS 的现实世界研究,从2004年到2022年
Zhongbiao Nie1, Cuilv Liang2, Zhihong Li1
1Department of Pharmacy, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, People's Republic of China.
Journal of pain research
|August 12, 2024
概括
这项研究发现 gabapentinoids 增加了妄想风险,特别是在老年人和男性中. 考虑到其他因素后,在大多数分析中,这种关联仍然显著,突出了潜在的安全问题.
科学领域:
- 药物监督 药物监督 药物监督
- 临床神经学 临床神经学
- 药品安全 药品安全
背景情况:
- 加巴丁类药物通常用于各种疾病.
- 妄想是一种严重的神经精神疾病,具有显著的发病率和死亡率.
- 了解药物诱导的妄想对于患者的安全至关重要.
研究的目的:
- 为了研究 gabapentinoid 使用与 Delirium 风险之间的关联.
- 评估不同患者人口统计和临床情景之间的相关性.
主要方法:
- 从2004年到2022年使用了FDA不良事件报告系统 (FAERS) 数据库.
- 采用了统计模型,包括报告几率比率 (ROR) 和比例报告比率 (PRR).
- 根据年龄和性别进行分组分析,并对混因素进行控制.
主要成果:
- 总共分析了2950份与 gabapentinoid 相关的痴呆症报告.
- 在最初的分析中,使用 gabapentinoid 与 Delirium 风险的增加有关 (RORs 从 1.09 到 1.54).
- 在老年人 (≥65岁) 和男性患者中,相关性仍然显著.
结论:
- gabapentinoids 与 Delirium 的发病率增加有关,特别是在老年人和男性人群中.
- 虽然考虑了混因素,但在大多数模型中风险仍然存在.
- 这凸显了在脆弱患者群体中对 gabapentinoid 诱导的妄想需要保持警.
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