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为遗传学研究定义自杀思想和行为表型
Eric T Monson1,2, Sarah M C Colbert3,4,5, Ole A Andreassen6,7
1Department of Psychiatry, University of Utah Spencer Fox Eccles School of Medicine.
medRxiv : the preprint server for health sciences
|August 12, 2024
概括
关于自杀念头,尝试和死亡的标准化定义对于自杀研究至关重要. 这项研究提供了专家建议,以改善数据的一致性并促进遗传研究.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 像自杀念头 (SI),尝试 (SA) 和死亡 (SD) 这样的自杀现象型缺乏标准化的定义.
- 这种异质性阻碍了研究,特别是评估临床和遗传风险因素.
- 在自杀研究中,标准化定义对于比较结果和组合样本至关重要.
研究的目的:
- 提出专家和数据支持的建议,用于定义自杀现象型 (SI,SA,SD) 和对照组.
- 为了方便合并现有和遗留样本的定义变化.
- 帮助创建未来的样本,以便进行更强大的自杀研究.
主要方法:
- 精神病基因组学联盟 (PGC) 的一个小组审查了SI,SA,SD和对照组的现有定义.
- 对于仪器衍生和国际疾病分类 (ICD) 数据,形成了共识指南.
- 基于ICD的SA定义在两个独立的数据集中得到验证 (N = 9,151和12,394).
主要成果:
- 为SA和SI的评估工具提供了建议,强调了终身测量和表型特定的措辞.
- 还提供了从ICD数据定义SI和SD的建议.
- 对SA ICD定义的验证显示了不同的灵敏度 (15.4%-80.6%),特异性 (67.6%-97.4%) 和正预测值 (0.59-0.93).
结论:
- 提供了最佳实践指南,用于在联盟研究中定义SI/SA/SD.
- 这些拟议的定义旨在促进基因和多站点研究更均的数据聚合.
- 未来的研究应该专注于在不同人群中改进,概括和验证这些定义.
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