细菌素的生产促进了抗菌素耐药的Enterococcus faecium在医院的出现
Emma G Mills1, Alexander B Smith2, Marissa P Griffith1,3,4
1Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
medRxiv : the preprint server for health sciences
|August 12, 2024
概括
抗万科米辛的Enterococcus faecium (VREfm) 医院菌株显示出随着时间的推移显著的血统转移. 细菌素T8可能会推动VREfm在医疗机构的出现和持续存在,影响感染控制策略.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 流行病学 流行病学
背景情况:
- 抗万科米辛的Enterococcus faecium (VREfm) 是一个主要的与医疗相关的病原体.
- 通过VREfm的胃肠道殖民可能导致严重的血液感染,死亡率高.
- 了解医院VREfm人口动态对于感染控制至关重要.
研究的目的:
- 为了研究医院适应VREfm群体的时间变化.
- 确定导致VREfm菌株在医疗机构出现和持续存在的因素.
- 将本地VREfm进化与全球趋势进行比较.
主要方法:
- 2017-2022年710个临床VREfm分离物的全基因组测序.
- 用15631个公开可用的VREfm基因组进行比较基因组分析.
- 功能分析以确定特定菌株的适应性特征.
主要成果:
- 该VREfm种群是多克隆的,其中46%的分离物形成了遗传相关的集群,这表明传播率高.
- 在20年的时间里,在本地和全球范围内观察到VREfm血统更换的显著转变.
- 抗微生物细菌素T8被确定为VREfm菌株出现和持久性的潜在驱动因素.
结论:
- 住院适应的VREfm种群在血统组成上经历了实质性的时间变化.
- 细菌素T8可能在医院环境中的特定VREfm菌株的成功中发挥关键作用.
- 这些发现对制定针对VREfm传播和感染的有针对性的干预措施有影响.
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