便calprotectin作为一个炎症生物标志物在小肠克朗氏病
相关实验视频
Updated: Jun 17, 2025

Investigating Intestinal Inflammation in DSS-induced Model of IBD
Published on: February 1, 2012
Maria I Sousa1,2, Emanuel Dias1, Patrícia Andrade1
1Gastroenterology Department, Centro Hospitalar Universitário de São João, Porto, Portugal.
便calprotectin (FC) 与小肠囊内镜 (SBCE) 在小肠克罗恩病 (CD) 中的发现有适度的相关性. 虽然FC可以预测炎症性病变,但没有特定的切断值显示出高灵敏度或特异性来诊断活跃疾病.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠病 (IBD) 的研究.
- 诊断生物标志物 诊断生物标志物
背景情况:
- 小肠囊内镜 (SBCE) 对于评估小肠克罗恩病 (CD) 是至关重要的.
- 便calprotectin (FC) 是肠道炎症的关键生物标志物,经常用于CD和性结肠炎.
- 这项研究调查了FC在诊断小肠中孤立的CD的活性炎症中的实用性.
研究的目的:
- 评估便calprotectin (FC) 在诊断孤立小肠克朗病 (CD) 患者的炎症活动中的作用.
- 为了将FC水平与小肠囊内镜 (SBCE) 的发现相关联.
主要方法:
- 在第三级IBD转诊中心进行了回顾性研究.
- 包括2017年1月至2023年2月期间接受SBCE的小肠CD患者.
- 从最接近SBCE日期的便样本中分析了FC水平.
主要成果:
- 包括196名患者;123名女性 (63%),平均年龄为44.2岁.
- FC水平与SBCE的易斯评分 (LS) 有显著的相关性 (皮尔森的r=0.43,P<.001).
- 对于FC (100,150,200μg/g) 的切线显示出不同的灵敏度和特异性,没有超过78%的灵敏度或67%的特异性.
结论:
- 便calprotectin显示SBCE中小肠克朗病的内镜发现与中度相关性.
- FC是预测SBCE检测到的显著炎症病变的合理标志物.
- 然而,目前的FC切断线缺乏高灵敏度和特异性,无法在这种情况下确定活跃炎症的确诊.
更多相关视频
07:05Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
Published on: December 15, 2017
08:58Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
相关概念视频
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Serum Laboratory Studies, Stool Test, Breath Test