免疫检查点抑制剂相关心肌炎的危险因素:综合性审查
Sara M Otto1, Ashely L Martinez1, Joyce E Dains1
1From The University of Texas MD Anderson Cancer Center, Houston, Texas.
Journal of the advanced practitioner in oncology
|August 12, 2024
概括
年长的癌症患者 (64岁以上) 的BMI超过28和之前的心血管药物使用面临更高的免疫检查点抑制剂 (ICI) 相关心肌炎的风险.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 是关键的癌症疗法.
- 心肌炎是ICI的罕见但严重的不良影响.
- 识别ICI相关心肌炎的危险因素对于患者安全至关重要.
研究的目的:
- 确定增加癌症患者免疫检查点抑制剂 (ICI) 相关心肌炎风险的因素.
- 为临床实践提供有关患者监测和风险分层的信息.
主要方法:
- 进行了综合性文献综述.
- 搜索的数据库包括PubMed,Scopus和Cochrane评论 (截至2022年3月1日).
- 纳入标准侧重于接受ICI的癌症患者的人类研究,确定心肌炎风险因素.
主要成果:
- 高龄 (64岁以上) 是一个重要的风险因素.
- 体重指数 (BMI) 大于28与风险增加有关.
- 心血管药物使用史也会增加风险.
结论:
- 虽然ICI相关心肌炎很少见,但具有很高的死亡风险.
- 需要进一步的研究,包括前性试验,以确认因果关系.
- 风险分层工具可以帮助早期识别和监测高风险患者.
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