在衰老和卵巢癌中的肠道微生物组
Gena M Dominique1, Catherine Hammond2, M Sharon Stack1
1Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN.
Aging and cancer
|August 12, 2024
概括
肠道微生物群随着衰老和卵巢癌的变化而变化,显示炎症增加和有益细菌减少. 需要更多的研究来将肠道细菌与卵巢癌的结果和衰老联系起来.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 老年学是一门学科.
背景情况:
- 肠道微生物组的组成随着年龄的增长而发生显著变化.
- 这些与年龄相关的肠道微生物组变化可以影响远处的组织,包括卵巢癌瘤微环境.
- 了解这些变化对于理解衰老和癌症进展至关重要.
研究的目的:
- 审查和综合有关卵巢癌和衰老的肠道微生物组的当前文献.
- 确定与这两种现象相关的微生物群组成的共同和对比的趋势.
- 突出关于因果关系和衰老与卵巢癌肠道微生物组之间的相互作用的研究缺口.
主要方法:
- 对卵巢癌中肠道微生物组研究的文献综述.
- 关于肠道微生物组在衰老中的研究的文献综述.
- 在两种情况下对微生物群趋势的比较分析.
主要成果:
- 卵巢癌和衰老都显示出促炎性细菌 (蛋白质细菌, * Escherichia *) 的增加和短链脂肪酸生产者的减少 (* Clostridium * XIVa集群, * Bifidobacterium *).
- 有益的细菌 (*Porphyromonadaceae*, *Akkermansia*) 随着健康的衰老而增加,但卵巢癌的减少,类似于不健康的衰老或肥胖.
- 在研究证明因果关系和在研究检查卵巢癌的肠道微生物组在衰老的背景下存在显著的差距.
结论:
- 肠道微生物组在卵巢癌和衰老中表现出明显但重叠的变化.
- 对因果关系和衰老-卵巢癌微生物组轴的进一步研究至关重要.
- 这种研究可能为卵巢癌诊断和治疗策略提供新的途径.
相关概念视频
02:07Oogenesis
63.6K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.6K
01:37Mitochondria
11.7K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
11.7K
02:17The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K