对年轻乳腺癌幸存者进行基于正念的干预的调解者:对抑郁症状的影响
J Richard T Korecki1, Patricia A Ganz, Ann H Partridge
1From the Department of Psychology (Korecki, Bower), UCLA, Los Angeles; UCLA Jonsson Comprehensive Cancer Center (Ganz, Petersen, Crespi, Bower); Department of Health Policy and Management (Ganz), UCLA Fielding School of Public Health; Department of Medicine, Division of Hematology-Oncology (Ganz), David Geffen School of Medicine at UCLA, Los Angeles, California; Department of Medical Oncology (Partridge), Dana-Farber Cancer Institute; Department of Medicine (Partridge), Brigham and Women's Hospital; Harvard Medical School (Partridge), Boston, Massachusetts; The Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center (Wolff), Baltimore, Maryland; Department of Biostatistics (Crespi), UCLA Fielding School of Public Health; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine (Bower), UCLA, Los Angeles; and Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior (Bower), Los Angeles, California.
基于正念的干预措施 (MBIs),如正念意识实践 (MAPs),有效地减少了年轻乳腺癌患者的抑郁症状. 关键的调解者包括减少反,减少侵入性思想,增加自我善良和和平.
科学领域:
- 在瘤学瘤学.
- 心理学 心理学 心理学
- 行为科学 行为科学
背景情况:
- 抑郁症对乳腺癌患者的结果产生负面影响,特别是在年轻女性中.
- 基于正念的干预措施 (MBI) 是有前途的,但它们减少抑郁症的机制尚不清楚.
- 本研究检查了特定MBI (MAPs) 和精神教育计划 (SE) 在年轻乳腺癌幸存者的调解者.
研究的目的:
- 调查反,自我善良,侵入性思维,癌症担忧,或意义/和平是否调解了MAP对抑郁症状的影响.
- 探索这些相同的变量作为SE计划的调解者.
- 了解这群人群中MBI有效性的基础机制.
主要方法:
- 随机对照试验包括247名女性 (乳腺癌0-III期,年龄<50岁).
- 干预组:MAPs (n=85),幸存者教育 (SE; n=81),等待名单控制 (WLC; n=81). 其他干预组:MAPs (n=85),幸存者教育 (SE; n=81),等待名单控制 (WLC; n=81).
- 在基线,干预后和6个月后的随访中对抑郁,反,自我善良,侵入性思想,担忧和意义/和平的评估.
主要成果:
- 在干预后,MAP和SE都显著降低了抑郁症状,MAP的影响在6个月的随访中持续.
- 通过减少反和侵入性思想,以及改善所有时间点的自我善良和意义/和平来调解MAP的影响.
- 焦虑 (干预后) 和侵入性思想 (随访6个月) 介导了SE的影响.
结论:
- 减少反,侵入性思想,增强自我善良和意义/和平是MAP在减少抑郁症有效性的关键调解者.
- 了解这些途径可以帮助优化乳腺癌患者的干预措施.
- 这些发现有助于在精神瘤学中对MBI的机制性理解.
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