酒精冲洗综合征与癌症之间的关联:系统性审查和元分析
Wilson Sim1, Jason Timothy Pan1, Cheryl Wan Xuan Chua1
1Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Annals of the Academy of Medicine, Singapore
|August 12, 2024
概括
酒精冲洗综合征 (AFS) 增加了癌症的风险,特别是食道和胃癌. 这种风险在男性和每周饮酒量超过200克的人群中较高.
科学领域:
- 遗传学和基因组学 遗传学和基因组学
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 酒精冲综合征 (AFS) 影响高达46%的东亚人.
- AFS与影响酒精代谢的遗传变异有关.
- 了解AFS对癌症风险的影响对于公共卫生至关重要.
研究的目的:
- 审查酒精冲洗综合征 (AFS) 患者的癌症风险.
- 为了确定AFS和酒精摄入量之间的暴露-反应关系.
- 了解与AFS和酒精消费模式相关的特定癌症风险.
主要方法:
- 观察性研究的系统审查和元分析.
- 在PubMed,Embase,Scopus和Cochrane图书馆的数据库中进行了搜索.
- 使用Mantle-Haenszel方法与随机效应模型组合数据.
主要成果:
- 分析了18项涉及387521名参与者的研究.
- AFS与所有癌症 (OR 1.19),食道状细胞癌 (OR 1.47) 和胃腺癌 (OR 1.40) 的风险增加有关.
- 在患有AFS的男性和每周消耗超过200克乙醇的人群中观察到癌症风险增加.
结论:
- 酒精冲综合征 (AFS) 与整体癌症的风险更高有关.
- 食道状细胞癌和胃腺癌在AFS患者的风险较高.
- 酒精消费水平显著改变了AFS患者的癌症风险.
相关概念视频
Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
Psychoneuroimmunology: Diabetes and Cancer
27
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
27
Adaptive Mechanisms in Cancer Cells
5.7K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.7K
Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Cancer Survival Analysis
334
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
334


