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Kristen Dominguez¹, Alexia N Pearah², April K Lindon¹

¹Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.

Infection and immunity

|August 12, 2024

概括

孕产妇补充丁酸盐可以减少B组链球菌 (GBS) 在新生儿的肠道殖民和入侵. 这种饮食策略可以加强肠道屏障功能,减轻新生儿败血症风险.

科学领域:

微生物学和免疫学
新生儿健康新生儿健康
胃肠病学胃肠病学

背景情况:

乙组链球菌 (GBS) 是新生儿败血症的主要原因,通常源于肠道殖民.
由于肠道壁垒未成熟,新生儿很容易受到影响,GBS可以利用这些障碍.
丁酸盐是一种微生物代谢物,增强了肠道屏障功能,可以在子宫内转移到胎儿.

研究的目的:

调查丁酸盐是否可以减轻GBS引起的肠道屏障破坏.
评估丁酸盐对GBS附着性,侵入性和上皮屏障完整性的影响.
在新生儿GBS败血症的小鼠模型中评估母乳丁酸盐治疗的疗效.

主要方法:

利用人类肠上皮细胞 (IEC) 线和肠状细胞来评估GBS与不含酸盐的影响.
测量了GBS诱导的细胞死亡,粘附,入侵和单层透性在体外.
采用一种小鼠模型,对母乳给予丁酸盐,以评估后代的GBS肠道负担.

主要成果:

丁酸盐在体外显著降低了GBS诱导的细胞死亡,入侵和单层透性.
在体外,丁酸盐在肠道上皮模型中降低了GBS转位.
在小鼠中,孕产妇的丁酸盐治疗导致新生儿后代的GBS肠道负担降低.

结论:

丁酸盐直接支持肠道上皮质屏障功能,对抗GBS.
孕产妇补充丁酸盐显示出降低新生儿GBS殖民和败血症风险的潜力.
像丁酸盐这样的食代谢物代表了对新生儿GBS感染的有前途的预防策略.

关键词:

黄油酸盐黄油酸盐是一种 B组链球菌链球菌肠道屏障肠道屏障肠道屏障新生儿败血症新生儿败血症

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