绘制中风结果:对大脑连接性地图集的审查
Triana Karnadipa1, Benjamin Chong1,2, Vickie Shim1
1Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.
概括
大脑连接图表显示,它有望预测中风的结果,但需要开发. 目前的地图集缺乏标准化,通常基于健康人群,限制了其中风预测准确度.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 康复科学 康复科学 康复科学
背景情况:
- 大脑连接图集对于理解神经通路和预测神经疾病结果越来越重要.
- 它们在预测中风后功能恢复中的应用是一个日益增长的研究领域.
研究的目的:
- 批判性地审查基于大脑连接的地图书的稳定性和局限性,以预测中风后的结果.
- 为了确定当前的差距和未来的方向,为中风患者群体开发更有效的地图.
主要方法:
- 从2012年到2023年5月,在主要数据库 (PubMed,Scopus,EMBASE,EBSCOhost,Medline) 中进行了全面的文献搜索.
- 分析了21项利用18个不同的大脑连接图谱进行中风预测结果的病变分析的研究.
- 根据队列,连接度,大脑区域,应用和局限性来评估地图集.
主要成果:
- 大多数审查的地图集使用了扩散张力成像和静止状态功能磁共振成像 (MRI).
- 用于多变量病变分析和区域识别,使用了地图集,通常来自年轻,健康的个体.
- 显著的局限性包括缺乏定义和绘制连接的标准化方法,以及对传感机动功能连接的有限覆盖.
结论:
- 目前的大脑连接图集还没有足够标准化或适应中风后人群.
- 需要开发更全面,更强大,更适应性更强的地图,专门为中风研究和临床应用而设计.
相关概念视频
01:20Anatomy of the Brain: Major Regions
The brain is the most complex organ in the human body. It consists of four main parts: the cerebrum, diencephalon, cerebellum, and brainstem.
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect various areas...
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect various areas...
01:11Cerebrum: Anatomical Overview II
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...