COVID-19疫苗接种和绝经后出血:一个回顾性队列研究
Lucía Pastor-Goutherot1, Ester Miralpeix1,2, Berta Fabregó2
1Pompeu Fabra University, Barcelona, Spain.
Climacteric : the journal of the International Menopause Society
|August 12, 2024
概括
接种COVID-19疫苗与更高的绝经后出血 (PMB) 发生率有关. 然而,该疫苗并没有增加子宫内膜癌症的风险,尽管建议对任何PMB进行子宫内膜活检.
科学领域:
- 妇科 妇科 妇科 妇科
- 生殖健康 生殖健康
- 疫苗学 疫苗学 疫苗学
背景情况:
- 在接种COVID-19疫苗后,有报道月经不规则.
- 接种COVID-19疫苗对绝经后妇女的影响,特别是对于绝经后出血 (PMB),仍然在很大程度上是未知的.
- 了解广泛疫苗接种计划的潜在副作用对于公共卫生至关重要.
研究的目的:
- 为了调查接受COVID-19疫苗接种后女性的绝经后出血 (PMB) 的患病率.
- 分析COVID-19疫苗接种和PMB发生在绝经后队列之间的关联.
- 评估子宫内膜病理与疫苗接种状态和PMB相关的情况.
主要方法:
- 一项回顾性研究包括381名绝经后妇女,分为接种疫苗 (n=91) 和未接种疫苗 (n=290) 组.
- 数据是在2021年2月至2022年1月期间收集的,PMB被定义为疫苗接种后30天以上发生的出血.
- 进行了统计分析,包括单变量和多变量回归,以确定PMB的风险因素.
主要成果:
- 疫苗接种组的PMB患病率明显高 (75.8%) 与未接种疫苗的组相比 (59.0%) (p < 0.005).
- 在接种疫苗的组中没有观察到恶性子宫内膜病理的统计显著增加 (p = 0.189).
- 多变量分析确定了COVID-19疫苗接种和恶性子宫内膜活检作为PMB的独立风险变量.
结论:
- 接种COVID-19疫苗与更年期后出血的患病率增加有关.
- 虽然接种疫苗与恶性子宫内膜病理的风险增加无关,但PMB需要进一步调查.
- 宫内膜活检仍然是评估绝经后出血的关键诊断工具,无论接种疫苗的情况如何.
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