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一种可逆电穿孔模型,用于将药物输送到患病组织中

Nilay Mondal^1,2, D C Dalal³

¹Department of Mathematics, Faculty of Science and Technology, The ICFAI University Tripura, Kamalghat, Agartala, Tripura, 799210, India. nilay.mondal@alumni.iitg.ac.in.

The Journal of membrane biology

|August 12, 2024

概括

本研究提出了一种使用可逆电穿孔的药物输送数学模型,优化药物输送到患病细胞并改善治疗结果.

科学领域:

生物医学工程生物医学工程
数学建模的数学建模
药物输送系统药物输送系统

背景情况:

电穿孔为向患病组织输送药物提供了一个有前途的方法.
在当前的电穿孔技术中,有效的药物透和细胞内吸收仍然是挑战.

研究的目的:

开发和验证一种基于可逆电穿孔的药物输送的数学模型.
研究组织边界和药物损失对药物运输的影响.
优化药物输送,使受影响组织得到完整和均的治疗.

主要方法:

开发了一个模拟可逆组织电穿孔的数学模型.
该模型包含在组织边界注射药物的点源.
数值解决方案被用来解决控制药物运输的微分方程.
推导了质量转移系数 (MTC),考虑到孔隙分数和药物透性.

主要成果:

该模型成功地使用多个脉冲模拟了药物透到目标细胞.
量化了药物度和细胞外药物损失的边界效应.
该模型预测了完整组织治疗的均药物分布.
确定了一个质量转移系数 (MTC),将毛孔分数和药物透性与细胞内药物吸收联系起来.

结论:

开发的数学模型准确地预测了可逆电穿孔过程中药物运输的情况.
该模型强调了边界条件和药物丧失机制的关键作用.
这种方法可以优化药物递送策略,可能减少对广泛的体内和体外研究的需要.

关键词:

药物输送是药物输送的过程.药物清除药物清除药物清除电穿孔是一种电子穿孔.大众运输是大众运输.多个脉冲多个脉冲.

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