铁甲酸盐非泡浮动迷你囊作为口服铁补充剂
Shital Trivedi1,2, Vijay Kevlani3, Shreeraj Shah4
1Research Scholar, Gujarat Technological University, Ahmedabad, 382424, Gujarat, India.
Drug delivery and translational research
|August 12, 2024
概括
开发了新的非发热浮式铁酸盐 (FA) 迷你囊片,以提高铁的生物可用性. 与立即释放配方相比,这些漂浮的迷你囊在体内显示出更好的铁吸收.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 生物制药生物制药公司
背景情况:
- 立即释放的铁制品通常具有较差的生物可用性.
- 铁酸盐 (FA) 是一种常见的铁补充剂,具有生物可用性挑战.
- 胃保留可以改善药物吸收.
研究的目的:
- 开发铁酸盐 (FA) 浮式微型囊,不发热.
- 使用低密度聚合物增强铁酸的生物可用性.
- 为了克服即时释放铁配方的局限性.
主要方法:
- 使用融化颗粒和低密度聚合物的配方开发.
- 使用全因数3^2实验设计进行优化.
- 通过体外药物释放,加速稳定性和子体内研究进行评估.
主要成果:
- 优化的配方 (F6) 在0.1N HCl中表现出即时和12小时的浮动持续时间.
- 实验室药物释放遵循扩散机制,在1小时释放30-35%,在5小时释放65-70%.
- 与对照组相比,体内研究显示血清铁的显著增加和UIBC的减少.
结论:
- 与立即释放配方相比,非泡漂浮的FA迷你囊显著提高了铁的生物可用性.
- 由于浮动而导致胃部长时间释放的铁有助于改善吸收.
- 这种新的配方为治疗铁缺乏症提供了一种有前途的方法.
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